Manchester United goalkeeper David de Gea will not play against Spurs amid ongoing interest from Real Madrid.
Bastian Schweinsteiger and Marcos Rojo are not considered fit enough but there could be debuts for Memphis Depay, Morgan Schneiderlin and Matteo Darmian.
Tottenham goalkeeper Hugo Lloris may start after returning from a fractured wrist in the midweek friendly win over AC Milan.
Toby Alderweireld, Kevin Wimmer and Kieran Trippier may feature in defence.
Ryan Mason, Roberto Soldado and Andros Townsend are all fitness doubts.
WHAT THE MANAGERS SAY
Manchester United manager Louis van Gaal: “I think that we are far better now than last year when we started, so I have a lot of confidence,
“When we play in the same style and at the same level as the last six months of last season, then we can make a good year.”
Manchester United beat Tottenham for the first time in six Premier League games with an impressive 3-0 victory at Old Trafford when the sides last met in March.
Spurs have won only five of their 46 Premier League games against United. However, their two victories at Old Trafford in that period both came in the last three seasons.
Manchester United lost at home on the opening weekend for the first time since 1972-73 when beaten by Swansea last season.
Louis van Gaal’s side finished fourth in 2014-15 with 70 points – three places and six points better off than the previous year.
Van Gaal used a league-high 33 players last season.
Wayne Rooney has scored six goals on the opening weekend, more than any other current Premier League player. He has scored 10 goals in 15 league appearances for United against Spurs.
Rooney has scored 170 league goals for United and needs one more to move alongside Denis Law in joint-third of the club’s all-time list.
Spurs could win their opening match in three consecutive top-flight seasons for the first time in the Premier League era.
They finished in the top six in 2014-15 for the sixth season in a row.
Tottenham had the youngest average starting line-up in the Premier League last season, aged 24 years and 281 days.
Only four clubs conceded more goals than Tottenham’s 53 in the Premier League last season.
Harry Kane’s 21 Premier League goals equalled Tottenham’s club record for most goals in a single campaign, level with Teddy Sheringham, Jurgen Klinsmann and Gareth Bale.
Kane’s goals earned his team 24 points, more than any other player in the Premier League last season.